{"id":197,"date":"2024-10-07T10:58:30","date_gmt":"2024-10-07T08:58:30","guid":{"rendered":"https:\/\/www.sclerodermie.net\/?page_id=197"},"modified":"2024-10-07T10:58:30","modified_gmt":"2024-10-07T08:58:30","slug":"role-des-populations-lymphocytaires-cytotoxiques-circulantes-dans-la-souffrance-endotheliale-au-cours-de-la-sclerodermie-systemique-scs","status":"publish","type":"page","link":"https:\/\/www.sclerodermie.net\/index.php\/role-des-populations-lymphocytaires-cytotoxiques-circulantes-dans-la-souffrance-endotheliale-au-cours-de-la-sclerodermie-systemique-scs\/","title":{"rendered":"R\u00f4le des populations lymphocytaires cytotoxiques circulantes dans la souffrance endoth\u00e9liale au cours de la scl\u00e9rodermie syst\u00e9mique (ScS)"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<p><strong>Porteuse du projet<\/strong>&nbsp;: Audrey BENYAMINE (abenyamine@ap-hm.fr)<\/p>\n\n\n\n<p><em>Service de M\u00e9decine Interne, H\u00f4pital Nord, CHU Marseille<\/em><br><em>Laboratoire d\u2019H\u00e9matologie du Pr Fran\u00e7oise Dignat-George,Universit\u00e9 d\u2019Aix-Marseille (AMU)<\/em><br><em>Vascular Research Center of Marseille (VRCM \u2013 UMRS1076)<\/em><\/p>\n\n\n\n<p><strong>Objectif<\/strong>&nbsp;: d\u00e9finir le r\u00f4le cytotoxique des populations lymphocytaires circulantes des patients atteints de ScS vis-\u00e0-vis de l\u2019endoth\u00e9lium.<\/p>\n\n\n\n<p><strong>&nbsp;Mat\u00e9riels et M\u00e9thodes&nbsp;:<\/strong> Nous \u00e9tudierons en cytom\u00e9trie en flux&nbsp;:<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/sclerodermie.net\/wp-content\/uploads\/2016\/01\/lymphocyte-T.png\" alt=\"lymphocyte T\" class=\"wp-image-3516\"\/><\/figure>\n<\/div>\n\n\n<p>-le pourcentage et le ph\u00e9notype des populations Lymphocytaires T (LT) \u03b3\u03b4 et Natural Killer (NK) de patients ScS <em>ex vivo<\/em> (<em>n<\/em>=15) et de t\u00e9moins sains (<em>n<\/em>=15) <strong>(Figure 1)<\/strong>.<br><\/p>\n\n\n\n<p>Ceci comprendra la caract\u00e9risation ph\u00e9notypique des LT \u03b3\u03b4 et NK (expression de marqueurs d\u2019activation, de r\u00e9cepteurs aux chimiokines, de r\u00e9cepteurs aux mol\u00e9cules d\u2019adh\u00e9sion endoth\u00e9liale, de r\u00e9cepteurs activateurs de cytotoxicit\u00e9)&nbsp;;<\/p>\n\n\n\n<p>-les interactions fonctionnelles cellules immunes cytotoxiques de patients ScS\/cellules endoth\u00e9liales <em>in vitro<\/em> (capacit\u00e9s cytotoxiques des LT \u03b3\u03b4 et NK, couples ligand\/r\u00e9cepteur impliqu\u00e9s, souffrance endoth\u00e9liale) <strong>(Figure 1 et 2).<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/sclerodermie.net\/wp-content\/uploads\/2016\/01\/LT2.png\" alt=\"LT2\" class=\"wp-image-3519\"\/><\/figure>\n<\/div>\n\n\n<p><strong>R\u00e9sultats attendus: <\/strong>Contribuer \u00e0 une caract\u00e9risation <strong>fonctionnelle<\/strong> des Lymphocytes T \u03b3\u03b4 et cellules NK, \u00e0 une meilleure compr\u00e9hension des processus de l\u00e9sion\/r\u00e9g\u00e9n\u00e9ration endoth\u00e9liale et au d\u00e9veloppement de biomarqueurs cibles dans la ScS.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Porteuse du projet&nbsp;: Audrey BENYAMINE (abenyamine@ap-hm.fr) Service de M\u00e9decine Interne, H\u00f4pital Nord, CHU MarseilleLaboratoire d\u2019H\u00e9matologie du Pr Fran\u00e7oise Dignat-George,Universit\u00e9 d\u2019Aix-Marseille (AMU)Vascular Research Center of Marseille (VRCM \u2013 UMRS1076) Objectif&nbsp;: d\u00e9finir [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-197","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/www.sclerodermie.net\/index.php\/wp-json\/wp\/v2\/pages\/197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sclerodermie.net\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.sclerodermie.net\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.sclerodermie.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sclerodermie.net\/index.php\/wp-json\/wp\/v2\/comments?post=197"}],"version-history":[{"count":1,"href":"https:\/\/www.sclerodermie.net\/index.php\/wp-json\/wp\/v2\/pages\/197\/revisions"}],"predecessor-version":[{"id":198,"href":"https:\/\/www.sclerodermie.net\/index.php\/wp-json\/wp\/v2\/pages\/197\/revisions\/198"}],"wp:attachment":[{"href":"https:\/\/www.sclerodermie.net\/index.php\/wp-json\/wp\/v2\/media?parent=197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}